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製品簡略説明
製品番号:70-020

Resume of DNA synthesis which was halted by various physical and chemical factors was triggered by repair system including Rad6. Rad6 (152a.a 17.3kDa) is the ubiqutin-conjugated enzyme E2A and complex with two Rad18 molecules ubiquitin ligase E3 to ubiquitinate PCNA by utilizing poly-ubiquitin chain that HLTF-UBC13 synthesized in translesion DNA synthesis (TLS) and template switch (TS). Two isoforms of RadA Rad6A and Rad6B differs in only 6 amino acids. It also plays an important role in epigenetic transcriptional regulation by catalyzing the monoubiquitination of histone H2B at Lys-120 for a formation of H2B K120 ub1.
Applications
1) Western blotting (1000 fold dilution)
2) Immunofluoscent staining (assay dependent)
Reactivity: Reacts with Rad6A and Rad6B of human and
rodents
Immunogen: Human Rad6B full-length recombinant protein
Purity: Affinity purified with the full-length human Rad6A
protein
Form: 1mg/ml in PBS 50% glycerol filter-sterilized
Storage: Shipped at 4℃. Upon arrival aliquot and store
at -20℃.
 
 
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容量
価格
 
70-020
100ug
39,000円(税抜)

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