Key words: CDC6 DNA replication Regulation of DNA replication Regulation of cycline-dependent kinase activity Phosphorylation Checkpoint Cell cycle Cell division. Mitosis ATP binding Nucleotide-triphosphatase activity Chromatin binding
Function: CDC6 (Cell Division Control Protein 6 homolog) (human; 560 aa 62.7 kDa) is involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Subcellular location: The protein is nuclear in G1 and cytoplasmic in S-phase cells.
1. Western blotting (1/1000~3000)
2. Immunoprecipitation （Assay dependent）
3. Immunofluorescence staining (1/100~1/1000 dilution)