Background: Involved in spindle disassembly degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD.
Cdc48 consists of 836 amino acids with molecular mass of 92 kDa.
1) Western blotting (1/500~1/5000 dilution). Not tested for other applications.
Product: Whole antiserum added with 0.02% sodium azide.
Immunogen: Synthetic peptide HPDQYTKFGLSPSK (509~521) corresponding to 509~521 of Cdc48 protein.
Reactivity: S. cerevisiae Cdc48 protein not tested in other species