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Code:71-113

p53 mutants are found in more than half of human cancers and are considered as the most important human cancer related gene. p53 is detected at 53kD position by electrophoresis and is composed of 393 amino acids. In the unstressed normal cells the p53 level is low and it is inactive. However with stress especially with DNA damage it is activated to promote arrest of cell cycle and repair of DNA damage or induction of apoptosis. The functions of p53 are regulated by phosphorylation of serine and threonine and acetylation of lysine at various sites in the molecule (1).
p53 at Ser20 is phosphorylated by Chk1 and Chk2 kinases and this enhances tetramerization stability and activity of p53 (2 3).
 
 
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71-113
100 ug
345 USD

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