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Information
Code:71-020

RagA (313 aa 36.6 kDa) is the human homologue of Gtr1 identified in yeast and classified as the Ras-like small G protein family. In cytoplasm GTP-bound RagA usually forms a heterodimer with RagD
interacts with Nop132 to be transported to the nucleous. GTP of RagA is hydrolyzed to GDP by RCC guanine nucleotide exchange factor for RanGTPase bound to chromatin. RagA-RCC signal pathway has a crucial role in cell growth and differentiation. RagA is also well known to be involved in mTOR signaling via binding with raptor a component of mTORC1 complex in an amino acid sensitive manner.
Applications
1) Western blotting ( 1000~ 2000 folds dilution)
Not tested for other applications
Reactivity: Reacts with mammalian and Xenopus Rag A proteins.
Immunogen: Purified full-length human RagA protein fused with GST
Form:::: Anti-Rag A rabbit serum added with 0.05% sodium azide.
Storage: Shipped at 4℃. Upon arrival aliquot and store at -20℃.
 
 
Code
Quantity
                  Price
 
71-020
100ul
330 USD

Product
 
Information
code:71-023

Key Words: GTP-Binding Protein mTORC1 TOR signaling cascade

Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids

Molecular mass: 44224 with 399 amino acids. Rag C forms a functional complex with Rag A and Rag B.

Cellular localization: Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus depending on the bound nucleotide state of associated RagA.

Post-translational modification: Acetylation and phosphorylation

Applications
1) Western blotting ( 1000~ 2000 folds dilution)
2) Immunofluorescence staining (1/100~1/500)
Not tested for other applications
 
 
Code
Quantity
                  Price
 
71-023
100 ul
345 USD

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