Registration
          
Cart
      
Infomation of Product
Sort
All topics:1 topics
1 topic~1 topics
Product
 
Information
Code:71-141

MdmX (synonyms: Mdm4 HdmX) inhibits p53-and p73-dependent cell cycle arrest and apoptosis by binding to the transcription activation domains of these proteins. MdmX consists of 490 amino acids with the molecular weight of 54864 and contains a RIING-finger domain and a nuclear transport signal. It is known that the protein migrates aberrantly in SDS-PAGE at the position of an 80-kDa protein. MdmX is phosphorylated at Ser367 by Chk2 kinase downstream of ATM in response to DNA damage and as a result it binds to14-3-3 and is transported into nucleus where it is degraded by Mdm2. This process activates the p53 functions (1 2 and 3).
 
 
Code
Quantity
                  Price
 
71-141
100 ug
345 USD

About Security  |   Policy  |   Escape  |   Site map  |   Address
Copyright(C) BioAcademia, Inc. 2006. All Rights Reserved.