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Molecular Biology / Cell Biology > Signal Transduction
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Information
Backgroud:Lamins are nuclear membrane proteins that serve to maintain nuclear structure and functions.
Lamin B receptor (LBR) is localized in the nuclear envelope inner membrane and anchors the lamina and heterochromatin to the membrane (1). It may mediate interaction between chromatin and lamin B (2). The interaction with lamin and chromatin is regulated by phosphorylation.

Applications
1)Western blotting (0.2~1 ug /ml)
2)Immunoprecipitation.
3)Indirect immuno-fluorescence staining
Other applications were not tested

Properties of the product
Antigen: Highly purified recombinant mouse LBR (amino acids 1-81)
Antibody: Affinity-purified with the recombinant LBR
Reactivity: Mouse and human. Not tested with other species
Form: 1.0 mg/ml in PBS 50% glycerol.

Reference
1. Worman HJ et al (1988) A lamin B receptor in the nuclear envelope. Pro.Natl.Acad.Sci. USA 85:8531
2. Pyrpasopoulou A et al. (1996) The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. EMBO J. 15: 7108-19
 
 
Code
Quantity
                  Price
 
70-301
50 ug
290 USD

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