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Code:71-151

E2F1 is a member of E2F group of proteins that share common structural and functional domains and plays a major role during the G1/S transition in the mammalian cell cycle as a transcriptional factor (1). E2F1 is regulated during cell cycle progression. It is phosphorylated at Ser364 by Chk2 kinase in response to DNA damage stabilized mobilized to nucleus and activated as a transcription factor (2). It induces apoptosis by activating transcription of the p53 homolog p73 (3). E2F1 protein consists of 437 amino acids with a molecular mass of 46 kDa.
 
 
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71-151
100 ug
345 USD

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Code:74-114

MAGE-G1 (melanoma-associated antigen G1 also designated necdin-like 2) gene encodes a necdin homologous protein. MAGE-G1 gene similarly to necdin gene has been mapped to the region of proximal chromosome 15q in human which is subject to genomic imprinting and implicated in various human neurological and mental disorders (ref.1). From this finding it is suggested that MAGE-G1 is involved in brain development and its abnormality causes neurodevelopmental diseases although its biochemical and functional features remain largely unknown. MAGE-G1 has characteristics similar to those of necdin which suppresses cell growth by inducing cell cycle arrest. MAGE-G1 like necdin targets both the transcription factor E2F1 and p75 neutrophin receptor (p75NTR) to regulate cell viability during brain development (ref.2). An antibody (named MG1) against mouse MAGE-G1 was raised in rabbit (ref.2).
 
 
Code
Quantity
                  Price
 
74-114
100 ul
345 USD

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