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Bacteriology / Bacterial Toxin Proteins > Bacterial Toxins
Product
 
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Code:64-010

Diphtheria toxin (535 aa 58 kDa) is an exotoxin secreted as a proenzyme by Corynebacterium diphtheriae the pathogen bacterium that causes diphtheria. The toxin gene is encoded by a bacteriophage. The proemzyme undergoes proteolytic nicking and reduction of disulfide bond giving rise to subunit A (21 kDa) and B (37 kDa). Subunit B (C-terminal) recognizes cellular receptor HB-EGF receptor and subunit A (N-terminal) catalyzes the ADP-ribosylation of eukaryotic elongation factor-2 (eEF2) inactivating this protein.
Applications:
1. Western blotting (1/2000 dilution).
2. ELISA (1/2000~1/7000 dilution. Could detect 1 ng or less of the toxin)
3. Immunoprecipitation (1/200~ 1/1000 dilution depending on assay)
4. Dot blotting (1/1000 dilution. Could detect 1 ng or less of the toxin)  
Immunogen: Purified nontoxic mutant Diphtheria toxin CRM 197 (Ref 1 Product #01-515)
 
 
Code
Quantity
                  Price
 
64-010
100ul
345 USD

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