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Code:74-114

MAGE-G1 (melanoma-associated antigen G1 also designated necdin-like 2) gene encodes a necdin homologous protein. MAGE-G1 gene similarly to necdin gene has been mapped to the region of proximal chromosome 15q in human which is subject to genomic imprinting and implicated in various human neurological and mental disorders (ref.1). From this finding it is suggested that MAGE-G1 is involved in brain development and its abnormality causes neurodevelopmental diseases although its biochemical and functional features remain largely unknown. MAGE-G1 has characteristics similar to those of necdin which suppresses cell growth by inducing cell cycle arrest. MAGE-G1 like necdin targets both the transcription factor E2F1 and p75 neutrophin receptor (p75NTR) to regulate cell viability during brain development (ref.2). An antibody (named MG1) against mouse MAGE-G1 was raised in rabbit (ref.2).
 
 
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74-114
100 ul
345 USD

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