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Code:74-112

MAGE-D1 (melanoma-associated antigen D1) also known as Dlxin-1 or NRAGE is a member of the MAGE protein family. MAGE-D1 is expressed in almost all normal adult tissues and has been demonstrated to interact with the p75 neutrophin receptor and to facilitate nerve growth factor-dependent apoptosis (ref.1). MAGE-D1 also interacts with its homologous protein necdin which is known as a growth suppressor and a promoter of differentiation in neurons. Necdin binds to Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors via MAGE-D1. These proteins cooperate to modulate differentiation of neurons and muscle cells by regulating gene expression whereas Msx proteins function as transcriptional repressor and Dlx proteins function as transcriptional activators (ref.2 and 3).
An antibody (named MD1) against mouse MAGE-D1 was raised in rabbit (ref.2).
 
 
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74-112
100 ul
345 USD

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