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Code:74-104

The Alzheimer amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known though it has been implicated as a regulator of synapse formation and neural plasticity. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates amyloid beta (A) a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer’s disease patients. Isoform APP695 lacking the protease inhibitor domain is the predominant form in neuronal tissues. An antibody (named AC1) against the C-terminus of human APP695 (aa 671-695) was raised in rabbit (2).
 
 
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74-104
100 ul
345 USD

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