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Code:71-175
RBP2 (1690 aa 192 kDa) was originally identified as a retinoblastoma binding protein. It is also known as JARID1A (Jumonji AT rich interactive domain 1A) and KDM5A (gene name). RBP2 plays both negative and positive roles in RB-mediated transcriptional activation depending on the kinds of genes and regulates differentiation by its function as an H3K4 histone demethylase.
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