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Code:70-415

Heterogeneous nuclear ribonucleoprotein U (hnRNP-U also known as scaffold attachment factor A SAF-A) is a nuclear matrix-associated protein that interacts with chromosomal DNA. hnRNP-U specifically binds to scaffold/matrix attachment region of DNA and could thus be involved in higher order chromatin structure. hnRNP-U is also a RNA binding protein and forms complexes with heterogeneous nuclear RNA (hnRNA) and plays an important role in pre-mRNA processing and transport.
HnRNP-U is reported to interact with necdin a growth suppressor that is expressed in terminally differentiated neurons and skeletal muscle cells. It has been shown that hnRNP-U recruits necdin to the nuclear matrix where they form a stable complex. It is suggested that necdin suppresses cell proliferation through its interaction with hnRNP-U in the specific subnuclear structure (ref.2).
 
 
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70-415
100 ul
330 USD

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