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70-115

Validation: Specificity was validated by western blotting with siRNA

Storage: Ship at 4℃ and aliquot and store at -20℃
Reactivity; Human and mouse rat hamster

Applications
1. Western blotting (1/200-1/2000 dilution).
2. Immunoprecipitation (assay dependent)
3. Immunofluorescence staining (1/100~1/1000 dilution)


Immunogen ; E. coli expressed and purified 6×His-tagged C-terminal 150 amino acids of human Cdt2
Form; Rabbit polyclonal antiserum added with 0.05 % sodium azide

Function; CDT2 (human 730 aa 79.5 kDa) is substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control DNA damage response and translesion DNA synthesis. The DCX(DTL) complex also named CRL4(CDT2) complex mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication.
 
 
Code
Quantity
                  Price
 
70-115
100 ul
350 USD

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