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code:70-107

Nuf2 is a component of kinetochore-associated Ndc80 complex which serves to attach microtubules to the kinetochore. Nuf2 is a conserved protein from yeast to human. Disruption of the Nuf2 gene in Schizosaccharomyces pombe causes defect in chromosome segregation and in the spindle checkpoint. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body and plays a regulatory role in chromosome segregation. In human cells Nuf2 specifically functions at kinetochores for stable microtubule attachment. Down regulation of the protein by RNA interference results in failure of the kinetochores to form attachments to the spindle microtubules. As a result cells are blocked in the prometaphase stage with an active spindle checkpoint and undergo cell death.
This antibody was prepared and tested by Prof. Tokuko Haraguchi at Kobe Advanced ICT Research Center National Institute of Information and Communications Technology
 
 
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70-107
100 ul
350 USD

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