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Code:65-058

Hepatitis C virus (HCV) is a small (55-65 nm in size) enveloped positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of hepatitis. The polyprotein encoded is processed by host cell and viral proteases into four structural proteins (core envelope1 and 2 and p7) and six non-structural proteins (NS2 3 4a 4b 5a and 5b) necessary for viral replication. NS4a protein (54 amino acids) forms a comlex with NS3 and functions as a cofactor for NS3 protease activity.

Applications
1. Western blotting 2. Immunofluorescence staining 3. ELISA 4. FACS

Immunogen: A region of NS4 protein (the nucleotide sequence is shown in ref.4) of HCV genotype 1b expressed in E. coli. The epitope of this antibody was mapped to the N-terminal region of the NS4 protein (NS4a).

Conjugate: Biotin conjugated [biotin] / [IgG] = 11.3

Isotype: Mouse IgG2b kappa

Form: 0.6 mg/ml in PBS 50% glycerol filter-sterilized

Specificity: Specific to human HCV NS4a protein of genotype 1b. Not tested in other genotypes.

 
 
Code
Quantity
                  Price
 
65-058
50 ug
310 USD

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