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Code:65-053

Hepatitis C virus (HCV) is a small (55-65 nm in size) enveloped positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A non-B hepatitis. The virus genome consists of a single open reading frame of approximately 94 kb which encodes a single polyprotein of about 3010 amino acids (1 2 3). The polyprotein is processed by host cell and viral proteases into four structural proteins (core envelope1 and 2 and p7) and six non-structural proteins (NS2 3 4a 4b 5a and 5b) necessary for viral replication. HCV core protein is not only a component of nucleocapsid but also has multiple functions and is a pathogenic factor for hepatitis. It also participates in some cellular processes including transcriptional regulation and cellular transduction. HCV core antigen is used as diagnostic marker for HCV infection.

Applications
1. Western blotting 2. Immunohistochemistry 3. Immuno-fluorescence staining
4. ELISA 5. FACS

Immunogen: A part of the core region (nucleotides 369-704 amino acids 13-124) of HCV genotype 1b expressed in E. coli

Conjugate: Bitin conjugated [biotin] / [IgG] = 6.6

Isotype: Mouse IgG2a kappa

Form: 0.7 mg/ml in PBS 50% glycerol filter-sterilized

Specificity: Specific to human HCV core antigen of genotype 1b. Not tested in other genotype
 
 
Code
Quantity
                  Price
 
65-053
50 ug
315 USD

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