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Code:63-141

Schizosaccharomyces pombe Sds22 protein contains leucine-rich repeats and physically interacts with the catalytic subunits of two type 1 protein phosphatases (Dis2 and Sds21). Sds22 is a regulatory subunit of these phosphatases and the Sds22-bound phosphatases carry a key phosphatase activity essential for the progression from metaphase to anaphase. Sds22 is essential for cell viability and in its absence cells were blocked in metaphase. Sds22 protein is predicted to form a repeating helical rod that is capable of enhancing a PP1-dependent dephosphorylation activity.
 
 
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63-141
100 ul
350 USD

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