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Molecular Genetics > Transcription・Translation
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Code:63-125 63-126

In the eukaryotic cells DNA is packaged repetitively into nucleosomes by means of interactions among two molecules of four classes of histone H2A H2B H3 and H4. Each of the histone proteins has an evolutionarily conserved amino-terminal ‘tail’ that protrudes from the nucleosome. This tail is the target of numerous diverse signaling pathways resulting in the addition of many post-translational modifications. These modifications include phosphorylation acetylation methylation ADP-ribosylation and mono-ubiquitination. Many important new modifications within the structured core and the carboxy-terminal tail regions of histones are also being identified. It is becoming increasingly clear that these modifications represent crucial regulatory events that govern the accessibility and function of the genome
Applications (see Ref 1)
1) Western blotting (1000 fold dilution). 2) Immunoprecipitation (CHIP assay).
Antigen: Synthetic peptide corresponding to the amino-terminal S. pombe histone H2B SAAEKKPASKAPAGKA
Reactivity: S. pombe histone H2B
Antibody: Undiluted rabbit antiserum added with 0.05 % sodium azide
Storage: -20℃ (long period -80℃)
Reference: This product has been used in the following reference.
1. Maruyama T. et al (Yanagida M). Histone H2B mutations in inner region affect ubiquitination centromere function silencing and chromosome segregation. EMBO J. 25: 2420-2431 (2006)
 
 
Code
Quantity
                  Price
 
63-125
50 μl
300 USD

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