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Background: The 26 S proteasome is a protein complex with a molecular mass of 2000 kDa. It is essential not only for eliminating damaged or misfolded proteins but also for degrading short lived regulatory proteins involved in cell cycle regulation DNA repair signal transduction apoptosis and metabolic regulation (1).Rpn3p is essential non-ATPase regulatory subunit of the 26S proteasome lid similar to the p58 subunit of the human 26S proteasome ( 2 3 4).
1) Western blotting (~1000 fold dilution) 2) Immunoprecipitation
3) Not tested for other application
Product: Rabbit antiserum
Immunogen: Recombinant yeast Rpn3p expressed in E. coli
Form: Rabbit serum added with 0.05 % sodium azide
React with: S. cerevisiae Rpn3p. Not tested with other species
Storage: -20℃. To avoid repeated freezing and thawing store the antibody in aliquots.
Reference: This product was used in ref. 3 and 4
1. Hershko A. and Ciechanover A. THE UBIQUITIN SYSTEM Annu. Rev. Biochem. 67 425-479 (1998)
2. Finley D et al. Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle.Trends Biochem Sci 23:244 (1998)
3. Glickman MH et al. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell 94 :615-23( (1998)
4. Isono E et al. Rpn7 Is required for the structural integrity of the 26 S proteasome of Saccharomyces cerevisiae. J Biol Chem. 279:27168-76 (2004)
100 ul
400 USD

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