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code:51-003

DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such it is part of the epigenetic code and is also the most well characterized epigenetic mechanism. DNA methylation involves the addition of a methyl group to DNA ― for example to the number 5 carbon of the cytosine pyrimidine ring ― in this case with the specific effect of reducing gene expression. In adult somatic tissues DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells. This hybridoma has been constructed by Prof. H. Sano.
Applications 
1) Immunocytochemistry (Figure below and Ref.1 & 2) (~50-100 fold dilution)
2) Immuno-blotting detection of DNA with 5-methylocytosine on nitrocellulose (Ref. 3 & 4) (~1000
fold dilution).
Immunogen: 5-Methylcytosine conjugated to bovine serum albumin (Ref 3)
Reactivity: DNA with 5-Methylcytosine (methylated DNA) any species
Isotype: IgM
Form: Purified mouse IgM 1 mg/ml in PBS with 50% glycerol filter-sterilized
Storage: -20℃ (long period -80℃)
 
 
Code
Quantity
                  Price
 
51-003
100 μg
345 USD

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