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Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-501

Storage: Shipped with ice-pack or dry-ice and store at -20℃ or
-80℃ (for longer period).

Applications:
1)Functional studies on the cAMP- signaling pathway (10~100 ng/ml)
2)Antigen for western blotting and ELISA
3)SDS-PAGE marker as native adenylate cyclase

Form: 550 μg/ml in 50 mM Tris-HCl(pH8.0) 6M urea 150 mM NaCl

Purity: More than 90% purity by SDS-PAGE (CBB staining)
 
 
Code
Quantity
                  Price
 
01-501
50 ug
250 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-503

Product: Highly purified (>90% pure) from Bordetera pertussis strain Tohama

Form: Solution of 135 ug/ml(depend on Lot) in 10% glycerol 10 mM phoshate buffer pH 7.4 137 mM NaCl

Application:
1.For the studies on the signal transduction involving the trimeric GTP-
binding proteins
2. Putative drugs to treat hypertention and autoimmune diseseases and
to prevent viral infection

 
 
Code
Quantity
                  Price
 
01-503
25 ug
440 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-505

Product:This Dermonecrotic toxin (DNT) is derived from Bordetella
bronchiseptica. This toxin activates smallGTP-binding proteins such as
RhoRac and Cdc42 through deamidation or polyamination for downstream
signaling pathways.

Applications:1)For the studies of the signaling pathways mediated
small GTP-binding proteins.2) Antigen for the detection of
Bordetera infection.

Activity: DNT at 5 ng/ml induces ballooning morphological change in cultured mouse osteoblastic cell line MC3T3-E1.

Form: 0.53 mg/ml in 50 mM Tris-HCl (pH 8.0) 6 M urea 150 mM NaCl .

 
 
Code
Quantity
                  Price
 
01-505
10 ug
440 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-507

Product: PMT( or dermonecrotic toxin (146 kD)) activates a subunit of the Gq and G12/13 protein which then activates the phospholipase C-b1 that controls several specific downstream signaling events.

Applications:For the studies on the GTP trimer bound protein dependent signaling pathways.

Form: 370 ug/ml in 50% glycerol 5mM Tris-HCl(pH7.5) 0.1M NaCl

Storage: -20℃ (long period; -80℃)

 
 
Code
Quantity
                  Price
 
01-507
50 ug
440 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-509

Clostridium perfringens enterotoxin (CPE) is a protein toxin produced by Gram-positive bacteriaC. perfringens. CPE destroys cell membrane structure of animals by its phospholipase activity after binding to the membrane of Claudin family proteins which are components of tight junction of epithelial cell membrane. CPE binds to Claudins 3 4 6 7 8 and 14 but not to Claudins 1 2 5 and 10.
 
Storage: Ship at 4℃ or -20℃ and store at -20℃ or
-80℃ (for long-term storage).

Applications
1. For the study of Claudin localization in cells
2. For the study of tight junctions
3. Western blot
4. SDS-PAGE .
5. ELISA

Form: 280 µg/ml in 50% glycerol 10 mM sodium phosphate buffer (pH 6.7)
 
 
Code
Quantity
                  Price
 
01-509
50 ug
440 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-511

Product: Highly purified (more tha 90% purity) from cultured medium
of Vibrio cholera strain 569B
The toxin is composed of one molecule of A-subunit (27.2
kD)responsible for binding to ganglioside of target cell and five
molecules of B-subunit (11.6 kD) constitutively activating adenylate
cyclase

Application:
1. Detection of GTP-binding protein Gsα
2. Detection of a low molecular weight GTP-binding protein ARF
3. To increase intracellular concentration of cyclic AMP of cultured
cell
Form: 1.0 mg/ml in 50 mM Tris-HCl (pH7.5) 0.2 M NaCl 1mM Na2EDTA
10% Glycerol 
 
 
Code
Quantity
                  Price
 
01-511
100 ug
310 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-513

Product: Highly purified (more than 90% pure) from growth medium of
Clostridium botulinum C strain
1.33 mg/ml in 50% glycerol 5 mM sodium phosphate buffer (pH 6.0)

Property: The C3 enzyme ADP-ribosylates a small GTP-binding protein Rho
and shuts down the downstream signal transduction pathway

Application: For the study on the signal transduction pathway dependent on Rho protein

Storage: -20℃ (long period -80℃)


 
 
Code
Quantity
                  Price
 
01-513
10 ug
165 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-515

Product:The CRM197 was highly purified (>95% pure) from cultured medium of Corynebacterium diphtheriae mutant CRM197.

Properties: CRM197 can bind to HB-EGF and inhibit the growth stimulating activity of HB-EGF without showing cellular toxicity.

Applications: 1. Inhibitor of HB-EGF
2. Candidate of anticancer drug for tumors whose growth
depends on HB-EGF

Form: 1.0 mg/ ml in 20 mM Tris-HCl (pH 7.2) 150 mM NaCl

Ship with dry-ice and store at -80℃
 
 
Code
Quantity
                  Price
 
01-515
200 ug
190 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
01-517

Product:Highly purified (>95% pure) from cultured medium of
Corynebacterium diphtheriae strain PW8

Properties: It is a 53 kD protein consisting of two subunits linked by disulfide bridges It catalyzes ADP-ribosylation of eukaryotic elongation factor 2 and inhibits protein synthesis.

Applications:1. Inhibition of protein synthesis of eukaryotes
2. Putative anti-cancer drug utilyzing strong immunotoxin activity

Form:2~ 5 mg/ml in 20 mM Tris-HCl (pH 7.2) 150 mM NaCl10% Glycerol
 
 
Code
Quantity
                  Price
 
01-517
200 ug
190 USD

Molecular Biology / Cell Biology > Signal Transduction
Product
 
Information
Code:63-101

Shipping and Storage : Ship at 4℃and upon arrival, aliquot and store at -20℃.

Reactivity: Swi6 protein of S. pombe

Immunogen: Recombinant full length protein corresponding to
Schizosaccharomyces pombe Swi6 aa 1-328

Applications  For the studies of RNAi mechanism
1. Western blotting (x 2,000~10,000 dilution) (Figure) Backgroud noise
was reduced with diluted antibody
2. Immunoprecipitation
3. Immunoflorescent staining
4.Chromatin Immuno-Precipitation

Form: Undiluted antiserum added with0.09% sodium azide
 
 
Code
Quantity
                  Price
 
63-101
50 ul
300 USD

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