Validation: Specificity validated with KO-mouse
Product: rabbit anti-IGSF8 antiserum added with 0.05% azide
1. Western blotting (1/500~1/1000 dilution))
2. Immunofluorescence staining (1/100 dilution). Not tested for other applications.
Function: IGSF8 may play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81 associates with CD82 to suppress prostate cancer cell migration regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Molecular mass: 65011 Da with 611 amino acids