PIAS4 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase stabilizing the interaction between UBE2I and the substrate and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways including the STAT pathway the p53/TP53 pathway the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA PARK7 HERC2 MYB TCF4 and RNF168. In Wnt signaling represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.Human
PIAS4 consists of 510 amino acids with molecular mass of 56504 Da.