Key words: TFIID subunit1 TAF1 CCG1 KAT4 TranscriptionTranscription initiation factor Transcription regulation Cell cycle Host-virus interaction protein kinase Bromo domain HMG box DNA-binding ATP-binding Nucleus Dystonia Parkinsonism
Function: TAFIID subunit1 (1872 aa 213 kDa) is the largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on Thr-55 which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
Involvement in diseases: Dystonia 3 torsion X-linked (DYT3) [MIM:314250]: A X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. It has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.
1) Western blotting (1/1000 dilution)
2) Immunofluorescent staining (1/1000~1/5000)
Other applications have not been tested