Varicella Zoster Virus (VZV) is one of eight herpesviruses known to infect humans and vertebrates. VZV only affects humans and commonly causes chickenpox in children teens and young adults and herpes zoster (shingles) in adults and rarely in children. VZV is known by many names including chickenpox virus varicella virus zoster virus and human herpesvirus type 3 (HHV-3).
VZV infects the nerves and causes a wide variety of symptoms. After the primary infection (chickenpox) the virus goes dormant in the nerves including the cranial nerve ganglia dorsal root ganglia and autonomic ganglia. Many years after the patient has recovered from chickenpox VZV can reactivate to cause a number of neurologic conditions
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis
gH is consists of 841 amino acids with molecular mass of 94 kDa